RNA Precipitation
- Treat trizol 300 ul/each well (format 12 well plate)
- Incubate 10 min on-ice
- Transfer trizol-cell lysate to e-tube [Pre-marked]
- Add 30 ul BCP solution into e-tube, vortex, and then keep on ice for
5 min
- Spindown at 12.000 g for 15 min
- Take e-tube back to ice, transfer Aquous phase (the upper
supernatant contain RNA) approximately 120 ul to a new e-tube
[Pre-marked]
- Put same volumes of Isopropanol with supernatant into e-tube
- Invert 5 times gently and then incubate for 10 min at room
temperature
- Spindown at 12.000 g for 8 min
- Look at the visible pellets, pour out whole supernatant
- Add 1 mL 75% EtOH in DEPC-treated water into e-tube
- After inverting, check pellets whether resuspended or not
- Spindown 7500 g for 5 min 14 Remove supernatant using pipet and dry
at room temperature
- Resuspend the pellet with 30 ul DEPC-treated water